Hormonal rigevidon. Drug rigevidon, instructions for use, contraindications. How to switch to Rigevidon from other birth control pills?

Name: Rigevidon

pharmachologic effect
Rigevidon is a drug from the group of combined drugs. oral contraceptives. Rigevidon is a monophasic drug, each tablet contains the same amount of estrogen and progestogen components. The drug contains levonorgestrel, a synthetic derivative of 19-nortestosterone, which has an activity similar to endogenous progesterone, but exceeds it in potency, which allows the use of levonorgestrel in minimal doses. In addition, the drug contains ethinyl estradiol, a synthetic analogue of endogenous estradiol. The drug effectively prevents pregnancy, the Pearl index is 0.1-0.9. When using the drug, a number of changes occur in a woman’s body that help prevent unwanted pregnancy, including suppression of ovulation, an increase in the viscosity of cervical mucus, and a decrease in the susceptibility of the endometrium to the blastocyst.
The mechanism of action of the drug is based on the pharmacological properties of the active components included in its composition. Thus, the drug blocks the release of releasing factors of the hypothalamus (luteinizing and follicle-stimulating hormone), inhibits the secretion of gonadotropic hormones by the pituitary gland, as a result of which the maturation of the follicle and its rupture slow down. Thus, the active components of the drug inhibit ovulation, preventing fertilization and pregnancy. In addition, the gestagenic component of the drug - levonorgestrel - helps to increase the viscosity of the cervical secretion, as a result of which it is difficult for sperm to penetrate into the uterine cavity, and also, by changing the structure of the endometrium, prevents the implantation of a fertilized egg.

If you are using a vaginal ring

If a patch becomes detached and you notice it within 24 hours, you can either reapply the same patch or replace it with a new patch. Then continue as before to apply your next patch on your regular "change day". If the patch has been off for more than 24 hours or if you don't know when it came off, start a new cycle by applying a new patch. You will also need to use another method of contraception, such as a condom, for the next seven days. This new patch is now your "Day 1" patch, and you must remember to change your patches on the same day of the week from now on. If you forget to apply the patch at the start of a new cycle, you will not be protected. If this happens, apply the Day 1 patch as soon as you remember and use another method of contraception, such as a condom, for the next seven days. If you have had sex while you were not wearing the patch, talk to your doctor or pharmacist for advice. If you forgot to change your patch on Day 8 or Day 15 but remember when it's less than 48 hours overdue, switch to the new patch right away and then remember to change it again on your regular change day. If you forgot to change the patch on day 8 or day 15, and you only remember when it's more than 48 hours overdue, you may not be protected. Remove the old patch and apply the new patch immediately. The new patch is now your "Day 1" patch, and you must remember to change your patches on the same day of the week from now on. If you forget to remove a patch at the end of a cycle, remove it as soon as you remember and start your next cycle on your regular "change day". Before inserting the ring, read the printed manufacturer's information leaflet from inside the package. This will give you more information about the vaginal ring and how to insert it correctly and also provide you with full list side effects that you may experience from using this. Insert one ring into your vagina on the first day of your cycle and then remove it for the day.

After seven days without the ring, start another cycle.
Be sure to check the ring regularly to make sure it stays in place.

What to do if the ring comes out.

In addition to the contraceptive effect, the drug, when used regularly, helps reduce the risk of developing various gynecological diseases (including reducing the risk of developing functional ovarian cysts, fibroadenomas and fibrocysts in the mammary glands, congestion in the pelvic organs) and reduces the frequency of dysmenorrhea and the amount of blood loss during menstruation. After a course of taking the drug, the risk decreases ectopic pregnancy. Even after long-term use of the drug, fertility is fully restored within 1-3 cycles after discontinuation of the drug.
The composition of the drug Rigevidon includes placebo tablets (7 placebo tablets per 21 tablets containing active substances) which, due to the content of iron salts, prevent the development of anemia, and also, due to the absence of hormones in them, help to increase the level of follicle-stimulating hormone in the body, which is necessary for selection of a dominant follicle. Thus, when using the drug Rigevidon, the development of “hyperinhibition” syndrome does not occur.

Getting the most out of your treatment

If your vaginal ring comes out but it is less than three hours old, rinse it in cool water and reinsert it immediately. If your vaginal ring comes out for more than three hours, you may not be protected from pregnancy. If this happens during week 1 or 2 of your cycle, rinse the ring with cool water and reinsert it. If this happens during the 3rd week of your cycle, you can start a new cycle by inserting a new ring, or you can resolve your period and then insert a new ring over the next seven days. If your ring breaks, remove it and insert a new ring immediately. Use another method of contraception, such as a condom, for the next seven days. If you forget to insert a new ring at the start of a new cycle, you will not be protected. If this happens, insert a new ring as soon as you remember and use another contraceptive method, such as a condom, for the next seven days. If you have had sex while you were not using the ring, talk to your doctor or pharmacist for advice. If you forget to remove a ring at the end of a cycle, remove it as soon as you remember and leave seven rings off. After seven days without a ring, another cycle begins. If you are late later in the week, you may no longer have to defend yourself. If this happens, talk to your doctor or pharmacist for advice. The vaginal ring can sometimes be felt by sexual partners, although this is usually not a problem. If you decide to remove the ring before engaging in sexual intercourse, make sure you replace it within three hours. If you suspect that you may be pregnant at any time, stop using contraception and call your doctor or pharmacist right away for a pregnancy test. Important: if you have an attack while sick or have diarrhea, it may reduce the effectiveness of this tablet. If you get sick within two hours of taking the tablet, take another tablet as soon as possible. If the illness continues or you have severe diarrhea that lasts more than 24 hours, you should also use another method of contraception. If this happens, use a condom if you have sex while sick and for seven days after you recover. If illness and diarrhea occur during the last week of your pills, skip seven pill-free days and start a new pack of oral contraceptives right away. If you are taking an everyday brand of pill, skip the seven inactive tablets. If you don't know what it is, or if you are unsure of the advice, talk to your doctor or pharmacist. Your doctor will discuss the risks of contraception with you and advise you on the most appropriate preparation for use. There is a slight increased risk of a clot in a blood vessel, although the risk is even lower than during pregnancy. Travel that involves long periods of sitting can add to the risk of a blood clot. It's always good idea Exercise your legs and ankles regularly when traveling, and you may want to wear nose guards during long flights. Before any surgery, you should tell your doctor or surgeon that you are using a combination hormone. If you are concerned about any of these issues, ask your pharmacist or doctor for advice about safe sex. If you buy any medications or herbal remedies, always check with your pharmacist that they can be taken safely with your contraceptive method. which can be purchased over the counter may interact with hormonal contraceptives, making them less effective and increasing the risk of unplanned pregnancy. An example of this is the herbal remedy called St. John's wort. Using a combined hormonal contraception may increase the risk of some cancers, but it will also protect against other types. Studies suggest a small increased risk of breast and cervical cancer, as well as protection against ovarian and endometrial cancer. Your doctor will be able to discuss the risks of each with you.

Can combined hormonal contraceptives cause problems?

You will not need to use any additional contraception.
Try to make regular appointments with your doctor or clinics.
This means your doctor can check your progress.
You will need to check your blood pressure from time to time.

Along with their beneficial effects, most medications can cause unwanted side effects, although not everyone experiences them.

The pharmacokinetics of the drug is based on the pharmacokinetic properties of the active components included in its composition:
Ethinyl estradiol after oral administration is rapidly absorbed from the gastrointestinal tract. Its bioavailability reaches 48%. The peak concentration of the active substance in the blood plasma is observed 1-1.5 hours after oral administration. After absorption into the bloodstream, ethinyl estradiol binds to plasma proteins, mainly albumin, a small part is in an unbound state. The first stage of metabolism occurs in the intestinal walls, the second in the liver, the most significant metabolites of ethinyl estradiol are OH-ethinyl estradiol and 2-methoxy-ethinyl estradiol. It is excreted both unchanged and in the form of metabolites in urine (about 40%) and feces (about 60%). The half-life is approximately 26 hours.
Levonorgestrel is well absorbed from the gastrointestinal tract, bioavailability is 100%. In blood plasma it binds predominantly to globulin and albumin. Metabolized in the body to form sulfate and glucuronide conjugates. Excreted in the form of metabolites in urine and feces.

The table below shows some of the most common cases associated with combined hormonal contraception. You will find a complete list in the manufacturer's information sheet that came with your medicine. Side effects often improve as your body adjusts to the new medicine, but talk to your doctor or pharmacist if any of the following continue or become bothersome.

Release form and composition

Important: Combined hormonal contraception can have serious side effects, but these are very rare. Other stomach pain Unusually painful or severe headache, or any loss of vision or hearing, or any difficulty swallowing. a bad fainting attack, a seizure or numbness on one side of your body, any yellowing of the skin or white eyes.

Any sudden or severe chest pain.
Any sudden shortness of breath or if you cough up any blood.
Any swelling or pain in the leg.

If you experience other symptoms that you think may be caused by contraception, discuss them with your doctor or pharmacist.

Indications for use
The drug is used as a means of contraception in women of childbearing age.
The drug can also be prescribed to correct functional disorders menstrual cycle, including dysmenorrhea, functional uterine bleeding, severe pain syndrome developing in the middle of the cycle, and premenstrual syndrome.
The drug is recommended for use in women with a moderately predominant estrogen phenotype.

How to store combined hormonal contraceptives

Important information about all medications

Keep all medications out of the reach of children.
Store in a cool, dry place, away from direct heat and light.

Rigevidon tablets contain two active ingredients: ethinyl estradiol and levonorgestrel. These are synthetic versions of the natural female sex hormones, estrogens and progesterone. Ethinyl estradiol is a synthetic version of estrogen, and levonorgestrel is a synthetic form of progesterone.

In a woman's normal menstrual cycle, sex hormone levels change throughout each month. Hormones cause the ovaries to release an egg and prepare the lining of the uterus for possible pregnancy. At the end of each cycle, if the egg is not fertilized, hormone levels drop, causing the lining of the uterus to shed as a monthly period. A daily dose of hormones taken in pills basically works by tricking your body into thinking that ovulation has already occurred. This prevents the egg from maturing and being released from the ovaries every month.

Mode of application
Before prescribing the drug Rigevidon, a general clinical and gynecological examination should be carried out, which must necessarily include monitoring blood pressure, determining glucose levels in the urine, a general blood and urine test, monitoring liver function, consultation with a mammologist and cytological analysis of smears.
The drug is taken orally, it is recommended to swallow the tablet whole, without chewing or crushing, with a sufficient amount of water. To achieve maximum effect, the drug should be taken at the same time of day.
As a contraceptive, the drug is prescribed 1 white tablet once a day, starting from the first or fifth day of menstruation. The duration of the course of taking white tablets is 21 days, after which you should take 1 tablet for 7 days red-brown color 1 per day. During the period of taking red-brown tablets, a woman experiences menstrual-like bleeding. If further contraception is necessary, after stopping taking the red-brown tablets, continue taking the drug according to the same regimen. You should not take a break between courses of taking the drug (a full course lasts 28 days - 21 white tablets and 7 red-brown tablets). The start of a new course should occur 4 weeks after the start of the previous one, on the same day of the week.
If you switch to taking Rigevidon after using another oral contraceptive, you should take the first white tablet on the first day of menstruation, and then take the drug according to the regimen described above.
If the drug is well tolerated, it can be taken for as long as there is a need for contraception.

Hormones also increase the thickness of the natural mucus on the cervix, making it difficult for sperm to travel from the vagina to the uterus and reach the egg. They also change the quality of the uterine lining, making it less likely that a fertilized egg can implant.

Rigevidone is a single-phase pill, which means that each pill has the same dosage of hormones in it. One tablet is taken every day for 21 days, followed by a 7-day break from taking the tablet. During the 7-day break, hormone levels drop and bleeding should be performed, which is similar to the normal period.

After an abortion, the drug is prescribed as soon as possible after the operation, but no later than the next day after the abortion.
The drug can be prescribed to women after childbirth, if they are not breastfeeding. In this case, taking the drug should begin no earlier than the first day of menstruation.
If you missed taking the next pill, you should take the drug as early as possible, however, if 36 hours or more have passed between doses of the drug, the effectiveness of the drug is significantly reduced and it is recommended to use an additional barrier method of contraception. To prevent the development of intermenstrual bleeding, you should continue taking the drug from the already started package, eliminating the missed tablet. If you miss a red-brown tablet, additional contraception is not required, since the red-brown tablets do not contain hormones. If vomiting or diarrhea develops while taking white tablets, the contraceptive effect of Rigevidon may be significantly reduced, in which case an additional non-hormonal method of contraception should be used.
When prescribing a drug for the treatment of functional disorders of the menstrual cycle, the duration of the course of treatment and the dose of the drug are determined by the attending physician individually for each patient.
With long-term use of the drug, patients should undergo a gynecological examination every six months; patients with impaired liver function should undergo control examinations every 2-3 months.
If after finishing taking the white tablets no menstrual bleeding occurs within 7 days, then continuing to take the drug is possible only after pregnancy has been ruled out.

The next pack of pills starts after the 7 days of free pills have ended, even if the bleeding is still ongoing. For ease of use, tablets come with a calendar marked by the day of the week, so it's easy to remember each day. It is advisable to take the tablet at the same time every day.

When to start taking Rigevidon

Rigevidone should be started on the first day of your menstrual cycle, which is the first day of your period. This provides immediate protection against unwanted pregnancy. It can be started up to day 5 of your cycle without the need for additional contraception. However, if you have a short menstrual cycle, this may not provide you with immediate birth control coverage and you should discuss this with your doctor.

Side effects
The drug is usually well tolerated, however, in some cases the following side effects may develop:
Side effects that develop mainly at the beginning of taking the drug and disappear within 1-3 courses:
From the gastrointestinal tract: nausea, vomiting, dyspepsia.
From the central and peripheral nervous system: headache, emotional lability, increased fatigue, irritability, cramps of the calf muscles. In addition, it is possible to both increase and decrease libido.

Others: breast engorgement, skin rash, intermenstrual bleeding, discomfort when wearing contact lenses.
Side effects that may occur with regular use of the drug:
Impaired glucose tolerance;
Hyperpigmentation of facial skin;
Changes in body weight (both increase and decrease in body weight are possible);
Increased concentration of triglycerides in the blood;
Arterial hypertension;
Thrombosis and thromboembolism of various locations (the risk of developing this side effect is higher in patients over 35 years of age, as well as in women who smoke);
Hepatitis, dysfunction of the gallbladder and biliary tract, diarrhea;
Alopecia;
Changes in vaginal secretion, fungal infections of the vaginal mucosa;
In addition, due to the fact that the red-brown tablets contain ferrous fumarate, stool may turn black.
If acute pain develops in the upper abdomen, it is necessary to exclude the presence of a liver tumor.

Contraindications
Increased individual sensitivity to the components of the drug.
Severe liver dysfunction, Dubin-Johnson syndrome and Rotor syndrome (congenital increase in the level of bilirubin in the blood), stones in the gall bladder, cholecystitis. Hepatitis, including those suffered within 6 months before prescribing the drug (prescribing the drug 6 months after hepatitis, is possible only if liver function is normalized).
Chronic colitis.
Severe diseases of the cardiovascular system, thromboembolism, cerebrovascular and oncological diseases, including a history.
Lipid metabolism disorders.
Severe arterial hypertension.
Diseases of the endocrine system, including diabetes.
Blood system disorders, including chronic hemolytic anemia and sickle cell anemia.
The drug is not prescribed to patients with vaginal bleeding of unknown origin.
Rigevidon is contraindicated in patients suffering from migraines and otosclerosis, including those who have experienced hearing impairment during previous pregnancies.
The drug should not be prescribed to patients with a history of idiopathic jaundice of pregnancy, as well as herpes and severe pruritus of pregnancy.

The drug is contraindicated in women whose close relatives have bleeding disorders and thromboembolism at a young age.
Taking the drug should be stopped 6 weeks before a planned surgical intervention, as well as in the event of pregnancy, with the development of thrombosis, thromboembolism and thrombophlebitis.
In addition, the drug should be discontinued if cerebrovascular disorders, myocardial infarction, visual impairment, retinal thrombosis, diplopia and exophthalmos develop.
Further use of the drug as a means of contraception is not recommended in the event of repeated severe headaches and the development of severe chronic diseases of various localizations.
The drug should be used with caution in women over 40 years of age, as well as with increased load on the vocal cords, and with diseases of the liver and biliary tract.
Prescribed with caution to patients with uterine fibroids, mastopathy and girls in adolescence, in the absence of regular ovulatory cycles.
In addition, caution should be exercised when prescribing the drug to patients suffering from epilepsy (including a history), depression, tuberculosis, ulcerative colitis, varicose veins, phlebitis, multiple sclerosis and kidney disease. Caution should also be exercised with intermittent porphyria, tetany and bronchial asthma.

Pregnancy
The drug is contraindicated for use during pregnancy. Before prescribing the drug, pregnancy should be excluded. You should stop taking Rigevidon at least 3 months before the planned pregnancy; during this period, you should use a non-hormonal method of contraception.
The drug is not used during breastfeeding, since its active components are released with breast milk. The use of the drug is possible only if the woman is not breastfeeding and has already had menstruation after childbirth.

Drug interactions
When using the drug simultaneously with antimicrobial drugs, including ampicillin, rifampicin, chloramphenicol, phenoxymethylpenicillin, sulfonamides, tetracyclines and neomycin, the contraceptive effect of Rigevidon may be reduced. If it is necessary to use these drugs, it is recommended to use a non-hormonal method of contraception or use barrier contraception, such as a condom, in addition to Rigevidon.
Dihydroergotamine, tranquilizers, phenylbutazone reduce the effectiveness of hormonal contraceptives.
With simultaneous use of the drug with anticoagulants, a group of coumarin derivatives or indanedione, it is possible to increase the effectiveness of the latter. When using these drugs simultaneously, the prothrombin time should be monitored and, if necessary, the dose of anticoagulants should be adjusted.

With the combined use of beta-blockers, maprotiline and tricyclic antidepressants with the drug Rigevidon, an increase in the bioavailability and toxicity of these drugs is observed.
When using the drug simultaneously with hypoglycemic oral drugs and insulin, it is necessary to monitor blood sugar levels and, if necessary, adjust the dose of insulin and oral hypoglycemic drugs.
When used in combination, the drug reduces the effectiveness of bromocriptine.
The drug, when used simultaneously with drugs that have a hepatotoxic effect, increases their toxicity (the risk of developing hepatotoxicity with this combination is highest in women over 35 years of age).
When prescribing iron supplements, the iron content in red-brown tablets should be taken into account.

Overdose
At the moment, no cases of overdose of the drug Rigevidon have been reported. If the drug is taken in doses significantly higher than recommended, patients may develop headache, nausea, vomiting, pain in the epigastric region and vaginal bleeding.
There is no specific antidote. In case of overdose, discontinuation of the drug, gastric lavage and administration of enterosorbents are indicated. If necessary, carry out symptomatic therapy.

Release form
Film-coated tablets, 28 pieces in a blister pack, 1 or 3 blister packs in a cardboard box. Each blister contains 21 film-coated tablets, white and 7 film-coated tablets, red-brown.
ethinyl estradiol, Levonorgestrel

Attention!
Description of the drug " Rigevidon"on this page is a simplified and expanded version official instructions by application. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

Before using the drug RIGEVIDON, you should consult your doctor. These instructions for use are for informational purposes only. For more complete information, please refer to the manufacturer's instructions.

RIGEVIDON: Clinical and pharmacological group

23.032 (Monophasic oral contraceptive)

RIGEVIDON: Release form, composition and packaging

White film-coated tablets, round, biconvex.

Excipients: colloidal silicon dioxide, magnesium stearate, talc, corn starch, lactose monohydrate.

Shell composition: sucrose, talc, calcium carbonate, titanium dioxide, copovidone, macrogol 6000, colloidal silicon dioxide, povidone, carmellose sodium.

21 pcs. - blisters (1) - cardboard packs. 21 pcs. - blisters (3) - cardboard packs.

RIGEVIDON: Pharmacological action

Combined monophasic oral hormonal contraceptive drug. When taken orally, it inhibits the pituitary secretion of gonadotropic hormones. The contraceptive effect is associated with several mechanisms. As a gestagenic component (progestin), it contains a derivative of 19-nortestosterone - levonorgestrel, which is more active than the corpus luteum hormone progesterone (and a synthetic analogue of the latter - pregnin), acts at the receptor level without preliminary metabolic transformations. The estrogenic component is ethinyl estradiol.

Under the influence of levonorgestrel, the release of LH and FSH from the hypothalamus is blocked, the secretion of gonadotropic hormones by the pituitary gland is inhibited, which leads to inhibition of the maturation and release of an egg ready for fertilization (ovulation). The contraceptive effect is enhanced by ethinyl estradiol. Maintains high viscosity of cervical mucus (makes it difficult for sperm to enter the uterine cavity). Along with the contraceptive effect, when taken regularly, it normalizes the menstrual cycle and helps prevent the development of a number of gynecological diseases, incl. tumor nature.

RIGEVIDON: Pharmacokinetics

After oral administration, levonorgestrel is rapidly absorbed (in less than 4 hours). Levonorgestrel does not undergo a first-pass effect through the liver. When levonorgestrel is co-administered with ethinyl estradiol, there is a relationship between the dose and maximum plasma concentration. Tmax (time to reach maximum concentration) of levonorgestrel is 2 hours, T1/2 - 8-30 hours (average 16 hours). Most of levonorgestrel binds in the blood to albumin and SHBG (sex hormone binding globulin).

Ethinyl estradiol is rapidly and almost completely absorbed from the intestine. Ethinyl estradiol undergoes a “first pass” effect through the liver, Tmax is 1.5 hours, T1/2 is about 26 hours.

When taken orally, ethinyl estradiol is cleared from the blood plasma within 12 hours, T1/2 is 5.8 hours.

Ethinyl estradiol is metabolized in the liver and intestines. Ethinyl estradiol metabolites are water-soluble sulfate or glucuronide conjugates that enter the intestine with bile, where they undergo disintegration with the help of intestinal bacteria.

Both components (levonorgestrel and ethinyl estradiol) are excreted in breast milk. Active substances are metabolized in the liver, T1/2 is 2-7 hours.

Levonorgestrel is excreted by the kidneys (60%) and through the intestines (40%); ethinyl estradiol - by the kidneys (40%) and through the intestines (60%).

RIGEVIDON: Dosage

The drug is taken orally at the same time of day, without chewing and with a small amount of liquid.

If hormonal contraception was not used during the previous menstrual cycle, then Rigevidon® for contraception is prescribed from the 1st day of menstruation, 1 tablet daily for 21 days. This is followed by a 7-day break, during which menstrual-like bleeding occurs. The next 21-day cycle of taking tablets from a new package containing 21 tablets must begin the day after the 7-day break, i.e. on the 8th day, even if the bleeding has not stopped. Thus, the start of taking the drug from each new package occurs on the same day of the week.

When switching to taking Rigevidon from another oral contraceptive, a similar scheme is used. The drug is taken as long as the need for contraception continues.

After childbirth, the drug can be prescribed only to women who are not breastfeeding; You should start taking the contraceptive no earlier than the 1st day of menstruation. During lactation, the use of the drug is contraindicated.

The missed pill should be taken within the next 12 hours. If 36 hours have passed since the last pill was taken, then contraception is unreliable. To avoid intermenstrual bleeding, the drug should be continued from the package already started, with the exception of the missed tablet(s). In cases of missed pills, it is recommended to additionally use another, non-hormonal method of contraception (for example, barrier).

For medicinal purposes, the doctor determines the dose of Rigevidon and the regimen of use in each case individually.

RIGEVIDON: Overdose

Cases of toxic effects due to overdose are unknown.

RIGEVIDONA: Drug interactions

Barbiturates, some antiepileptic drugs (carbamazepine, phenytoin), sulfonamides, pyrazolone derivatives can enhance the metabolism of the steroid hormones included in the drug.

A decrease in contraceptive effectiveness can also be observed when administered simultaneously with certain antimicrobial agents (including ampicillin, rifampicin, chloramphenicol, neomycin, polymyxin B, sulfonamides, tetracyclines), which is associated with changes in intestinal microflora.

When used simultaneously with anticoagulants, coumarin or indanedione derivatives, additional determination of the prothrombin index and a change in the dose of the anticoagulant may be required.

When using tricyclic antidepressants, maprotiline, beta-blockers, their bioavailability and toxicity may increase.

When using oral hypoglycemic drugs and insulin, it may be necessary to change their dose.

When combined with bromocriptine, its effectiveness decreases.

When combined with drugs with potential hepatotoxic effects, for example, with the drug dantrolene, an increase in hepatotoxicity is observed, especially in women over 35 years of age.

RIGEVIDONA: Pregnancy and lactation

The drug is contraindicated during pregnancy and lactation (breastfeeding).

RIGEVIDON: Side effects

The drug is usually well tolerated.

Possible transient nature, spontaneously passing: nausea, vomiting, headache, engorgement of the mammary glands, changes in body weight and libido, mood changes, acyclic bleeding; in some cases - swelling of the eyelids, conjunctivitis, blurred vision, discomfort when wearing contact lenses (these phenomena are temporary and disappear after discontinuation without prescribing any therapy).

With long-term use, chloasma, hearing loss, generalized itching, jaundice, calf muscle cramps, and an increase in the frequency of epileptic seizures can very rarely occur.

Hypertriglyceridemia, hyperglycemia, decreased glucose tolerance, increased blood pressure, thrombosis and venous thromboembolism, jaundice, skin rashes, changes in the nature of vaginal secretion, candidiasis, fatigue, diarrhea are rarely observed.

RIGEVIDON: Storage conditions and periods

The drug should be stored out of the reach of children at a temperature of 15° to 30°C. Shelf life - 5 years.

RIGEVIDON: Indications

oral contraception;
functional disorders of the menstrual cycle (incl.
dysmenorrhea without an organic cause,
dysfunctional metrorrhagia);
premenstrual tension syndrome.

RIGEVIDON: Contraindications

severe liver disease;
congenital hyperbilirubinemia (Gilbert's syndrome,
Dubin-Johnson syndrome,
Rotor syndrome);
cholecystitis;
presence or history of severe cardiovascular and cerebrovascular diseases;
thromboembolism and predisposition to them;
malignant tumors (primarily breast or endometrial cancer);
liver tumors;
familial forms of hyperlipidemia;
severe forms of arterial hypertension;
endocrine diseases (incl.
severe forms of diabetes);
sickle cell anemia;
chronic hemolytic anemia;
vaginal bleeding of unknown etiology;
hydatidiform mole;
migraine;
otosclerosis;
history of idiopathic jaundice in pregnancy;
severe skin itching during pregnancy;
herpes during pregnancy;
age over 40 years;
pregnancy;
lactation period (breastfeeding);
hypersensitivity to the components of the drug.

The drug should be used with caution in diseases of the liver and gall bladder, depression, ulcerative colitis, uterine fibroids, mastopathy, tuberculosis, kidney disease, diabetes mellitus, diseases of the cardiovascular system, arterial hypertension, renal dysfunction, varicose veins, phlebitis, otosclerosis, multiple sclerosis, epilepsy, chorea minor, intermittent porphyria, latent tetany, bronchial asthma, in adolescence (without regular ovulatory cycles).

RIGEVIDON: Special instructions

Before starting the use of hormonal contraception and subsequently every 6 months, a general medical and gynecological examination is recommended, including a cytological analysis of a smear from the cervix, assessment of the condition of the mammary glands, determination of blood glucose, cholesterol and other indicators of liver function, blood pressure monitoring, and urine analysis.

Prescribing Rigevidon to women with thromboembolic diseases at a young age and a family history of increased blood clotting is not recommended.

The use of oral contraception is allowed no earlier than 6 months after viral hepatitis, provided that liver functions are normalized.

If sharp pain appears in the upper abdomen, hepatomegaly and signs of intra-abdominal bleeding, a suspicion of a liver tumor may arise. If necessary, the drug should be discontinued.

If liver function is impaired while taking Rigevidon, consultation with a physician is necessary.

If acyclic (intermenstrual) bleeding occurs, Rigevidon should be continued, because in most cases, these bleedings stop spontaneously. If acyclic (intermenstrual) bleeding does not disappear or recurs, a medical examination should be performed to exclude organic pathology of the reproductive system.

In case of vomiting or diarrhea, the drug should be continued using another, non-hormonal method of contraception.

In women who smoke and take hormonal contraceptives, there is an increased risk of developing cardiovascular diseases with serious consequences (myocardial infarction, stroke). The risk increases with age and depending on the number of cigarettes smoked (especially in women over 35 years of age).

The drug should be stopped in the following cases:

when a migraine-like headache appears for the first time or worsens;
when an unusually severe headache appears;
when early signs phlebitis or phlebothrombosis (unusual pain or swelling of the veins in the legs);
if jaundice or hepatitis without jaundice occurs;
for cerebrovascular disorders;
when stabbing pain of unknown etiology appears when breathing or coughing,
pain and tightness in the chest;
with acute deterioration of visual acuity;
if thrombosis or heart attack is suspected;
with a sharp increase in blood pressure;
when generalized itching occurs;
with increased frequency of epileptic seizures;
3 months before the planned pregnancy;
approximately 6 weeks before the planned surgical intervention;
with prolonged immobilization;
during pregnancy.

Impact on the ability to drive vehicles and operate machinery

Taking the drug does not affect the ability to drive Vehicle and to control other mechanisms, work with which is associated with an increased risk of injury.

RIGEVIDON: Use for impaired renal function

Caution is required when prescribing the drug to patients with impaired renal function.

RIGEVIDON: Use for liver dysfunction

Contraindicated for use in severe liver diseases (including congenital hyperbilirubinemia - Gilbert, Dubin-Johnson and Rotor syndromes; liver tumors).